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1

The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice

Jiri Kassa, Jana Zdarova Karasova, Ruzena Pavlikova, Jan Misik, Filip Caisberger, Jiri Bajgar

Journal:

Journal of Applied Toxicology

Year:

2010

Language:

english

File:

PDF, 191 KB

english, 2010

2

The influence of low-level sarin inhalation exposure on spatial memory in rats

Jiří Kassa, M Koupilova, J Vachek

Journal:

Pharmacology Biochemistry and Behavior

Year:

2001

Language:

english

File:

PDF, 198 KB

english, 2001

3

Synthesis of a New Reactivator (I) of Tabun-Inhibited Acetylcholinesterase.

Kamil Kuca, Jiri Bielavsky, Jiri Cabal, Jiri Kassa

Journal:

Year:

2004

File:

PDF, 75 KB

2004

4

Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain

Kamil Kuca, Jiri Cabal, Jiri Kassa, Daniel Jun, Martina Hrabinová

Journal:

Journal of Applied Toxicology

Year:

2005

Language:

english

File:

PDF, 150 KB

english, 2005

5

In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions

Kamil Kuca, Jiri Cabal, Daniel Jun, Jiri Kassa, Lucie Bartosová, Gabriela Kunesová

Journal:

Journal of Applied Toxicology

Year:

2005

Language:

english

File:

PDF, 136 KB

english, 2005

6

A comparison of the potency of newly developed oximes (K027, K048) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats

Jiří Kassa, Gabriela Kunesova

Journal:

Journal of Applied Toxicology

Year:

2006

Language:

english

File:

PDF, 115 KB

english, 2006

7

The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats

Jiri Kassa, Jana Karasova, Libor Vasina

Journal:

Journal of Applied Toxicology

Year:

2007

Language:

english

File:

PDF, 187 KB

english, 2007

8

Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells

Jaroslav Pejchal, Jan Osterreicher, Jiri Kassa, Ales Tichy, Stanislav Micuda, Zuzana Sinkorova, Lenka Zarybnicka

Journal:

Journal of Applied Toxicology

Year:

2009

Language:

english

File:

PDF, 422 KB

english, 2009

9

Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy

Miroslav Pohanka, Jana Zdarova Karasova, Kamil Musilek, Kamil Kuca, Jiri Kassa

Journal:

Journal of Applied Toxicology

Year:

2009

Language:

english

File:

PDF, 337 KB

english, 2009

10

Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent

Hee Chun Jeong, No-Joong Park, Chong Hak Chae, Kamil Musilek, Jiri Kassa, Kamil Kuca, Young-Sik Jung

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 259 KB

english, 2009

11

A comparison of the potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats

Jiri Kassa, Jana Karasova

Journal:

Year:

2007

Language:

english

File:

PDF, 195 KB

english, 2007

12

An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice

Jiri Kassa, Jana Karasova, Kamil Musilek, Kamil Kuca

Journal:

Year:

2008

Language:

english

File:

PDF, 184 KB

english, 2008

13

A comparison of the efficacy of pyridostigmine alone and the combination of pyridostigmine with anticholinergic drugs as pharmacological pretreatment of tabun-poisoned rats and mice

Jirı́ Kassa, J Vachek

Journal:

Year:

2002

Language:

english

File:

PDF, 80 KB

english, 2002

14

Low-level sarin-induced alteration of immune system reaction in inbred BALB/c mice

Jiřı́ Kassa, Z Kročová, L Ševelová, V Sheshko, I Kasalová, V Neubauerová

Journal:

Year:

2003

Language:

english

File:

PDF, 208 KB

english, 2003

15

Importance of cholinolytic drug selection for the efficacy of HI-6 against soman in rats

Journal:

Year:

1997

Language:

english

File:

PDF, 505 KB

english, 1997

16

Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase

Kamil Kuča, Jiřı́ Bielavský, Jiřı́ Cabal, Jiřı́ Kassa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

17

Neuroprotective Effects of Currently Used Antidotes in Tabun-Poisoned Rats

Jiří Kassa, Gabriela Krejèová

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2003

Language:

english

File:

PDF, 72 KB

english, 2003

18

Changes of acetylcholinesterase activity in various parts of brain following nontreated and treated soman poisoning in rats

Jiří Kassa, Jiří Bajgar

Journal:

Molecular and Chemical Neuropathology (Neurochemical Pathology)

Year:

1998

Language:

english

File:

PDF, 807 KB

english, 1998

19

The influence of oxime and anticholinergic drug selection on the potency of antidotal treatment to counteract acute toxic effects of tabun in mice

Journal:

Neurotoxicity Research

Year:

2006

Language:

english

File:

PDF, 885 KB

english, 2006

20

Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases

Kamil Kuca, Jiri Cabal, Daniel Jun, Jiri Bajgar, Jiri Kassa, Josef Fusek

Journal:

Year:

2007

Language:

english

File:

PDF, 61 KB

english, 2007

21

The Efficacy of Monopyridinium (2-PAAM, 2-PAEM) and Bispyridinium (Obidoxime, HI-6) Oximes against Mevinphos in Mice

Jiří Kassa, Jiří Bielavský

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1997

Language:

english

File:

PDF, 302 KB

english, 1997

22

Toxic Effects of Sarin in Rats at Three Months Following Single or Repeated Low-Level Inhalation Exposure

Jiří Kassa, Miroslav Pecka, Miloš Tichý, Jiří Bajgar, Marie Koupilová, Josef Herink, Zuzana Kročová

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2001

Language:

english

File:

PDF, 102 KB

english, 2001

23

Specification of the Structure of Oximes Able to Reactivate Tabun-Inhibited Acetylcholinesterase

Jiří Cabal, K. Kuča, J. Kassa

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2004

Language:

english

File:

PDF, 83 KB

english, 2004

24

The Influence of Single or Repeated Low-Level Sarin Exposure on Immune Functions of Inbred BALB/c Mice

Jiří Kassa, Z. Kročová, L. Ševelová, V. Sheshko, I. Kasalová, V. Neubauerová

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2004

Language:

english

File:

PDF, 73 KB

english, 2004

25

Comparison of Reactivating and Therapeutic Efficacy of Two Salts of the Oxime HI-6 against Tabun, Soman and Cyclosarin in Rats

Jiri Kassa, Daniel Jun, Kamil Kuca, Jiri Bajgar

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2007

Language:

english

File:

PDF, 70 KB

english, 2007

26

The Influence of Acetylcholinesterase Reactivators on Selected Hepatic Functions in Rats

Jaroslav Pejchal, Jan Osterreicher, Kamil Kuca, Daniel Jun, Jiri Bajgar, Jiri Kassa

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2008

Language:

english

File:

PDF, 116 KB

english, 2008

27

Evaluation of the Neuroprotective Efficacy of Newly Developed Oximes (K206, K269) and Currently Available Oximes (Obidoxime, HI-6) in Cyclosarin-Poisoned Rats

Jiri Kassa, Jana Zdarova Karasova, Jiri Bajgar, Sandra Tesarova, Kamil Kuca, Kamil Musilek

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2009

Language:

english

File:

PDF, 103 KB

english, 2009

28

A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats

Jiri Kassa, Jana Zdarova Karasova, Sandra Tesarova, Kamil Musilek, Kamil Kuca, Young-Sik Jung

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2010

Language:

english

File:

PDF, 122 KB

english, 2010

29

The Benefit of Combinations of Oximes for the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Sarin Poisoning in Rats and Mice

Jiri Kassa, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2011

Language:

english

File:

PDF, 108 KB

english, 2011

30

A comparison of the reactivating efficacy of a novel bispyridinium oxime K203 with currently available oximes in VX agent-poisoned rats

Kassa, Jiri, Zdarova Karasova, Jana, Sepsova, Vendula

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 657 KB

english, 2012

31

A Comparison of the Potency of a Novel Bispyridinium Oxime K203 and currently available Oximes (Obidoxime, HI-6) to Counteract the Acute Neurotoxicity of Sarin in Rats

Jiri Kassa, Jan Misik, Jana Zdarova Karasova

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2012

Language:

english

File:

PDF, 600 KB

english, 2012

32

(09) Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo

Kamil Kuca, Lucie Bartosova, Jiri Kassa, Jiri Cabal, Jiri Bajgar, Gabriela Kunesova, Daniel Jun

Journal:

Chemico-Biological Interactions

Year:

2005

Language:

english

File:

PDF, 90 KB

english, 2005

33

(22) Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species

Daniel Jun, Kamil Kuca, Jiri Cabal, Lucie Bartosova, Gabriela Kunesova, Jiri Kassa

Journal:

Chemico-Biological Interactions

Year:

2005

Language:

english

File:

PDF, 134 KB

english, 2005

34

A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats

Jiri Kassa, Daniel Jun, Jana Karasova, Jiri Bajgar, Kamil Kuca

Journal:

Chemico-Biological Interactions

Year:

2008

Language:

english

File:

PDF, 167 KB

english, 2008

35

An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents

Jiri Bajgar, Josef Fusek, Jiri Kassa, Daniel Jun, Kamil Kuca, Petr Hajek

Journal:

Chemico-Biological Interactions

Year:

2008

Language:

english

File:

PDF, 218 KB

english, 2008

36

Evaluation of flow injection analysis for determination of cholinesterase activities in biological material

Jiri Cabal, Jiri Bajgar, Jiri Kassa

Journal:

Chemico-Biological Interactions

Year:

2010

Language:

english

File:

PDF, 210 KB

english, 2010

37

Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo

Jiri Bajgar, Jana Zdarova Karasova, Jiri Kassa, Jiri Cabal, Josef Fusek, Vaclav Blaha, Sandra Tesarova

Journal:

Chemico-Biological Interactions

Year:

2010

Language:

english

File:

PDF, 116 KB

english, 2010

38

A Comparison of the Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase with Commonly Used Pyridostigmine as Pharmacological Pre-Treatment of Soman-Poisoned Mice

Jiri Kassa, Kamil Musilek, Marketa Koomlova, Jiri Bajgar

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2012

Language:

english

File:

PDF, 152 KB

english, 2012

39

Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex

Aline P. da Silva, Marcelo Farina, Jeferson L. Franco, Alcir L. Dafre, Jiri Kassa, Kamil Kuca

Journal:

NeuroToxicology

Year:

2008

Language:

english

File:

PDF, 284 KB

english, 2008

40

Effect of 10 oxime cholinesterase reactivators on cyclosarin-intoxicated rats

Jana Zdarova Karasova, Jiri Kassa, Kamil Musilek, Miroslav Pohanka, Kamil Kuca

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 94 KB

english, 2009

41

The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

Kassa, Jiri, Sepsova, Vendula, Musilek, Kamil, Horova, Anna

Journal:

Toxicology Mechanisms and Methods

Year:

2013

Language:

english

File:

PDF, 706 KB

english, 2013

42

A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice

Kassa, Jiri, Karasova, Jana Zdarova, Pavlikova, Ruzena, Musilek, Kamil, Kuca, Kamil, Bajgar, Jiri, Jung, Young-Sik

Journal:

Toxicology Mechanisms and Methods

Year:

2011

Language:

english

File:

PDF, 620 KB

english, 2011

43

Design of a Potent Reactivator of Tabun-Inhibited AcetylcholinesteraseSynthesis and Evaluation of ( E )-1-(4-Carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)

Musilek, Kamil, Jun, Daniel, Cabal, Jiri, Kassa, Jiri, Gunn-Moore, Frank, Kuca, Kamil

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 64 KB

english, 2007

44

Evaluation of the Potency of Two Novel Bispyridinium Oximes (K456, K458) in Comparison with Oxime K203 and Trimedoxime to Counteract Tabun-Induced Neurotoxicity in Rats

Kassa, Jiri, Misik, Jan, Karasova, Jana Z.

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2013

Language:

english

File:

PDF, 168 KB

english, 2013

45

In Vitro Potency of H Oximes (HI-6, HLö-7), the Oxime BI-6, and Currently Used Oximes (Pralidoxime, Obidoxime, Trimedoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase

Kuca, Kamil, Cabal, Jiri, Kassa, Jiri, Jun, Daniel, Hrabinova, Martina

Journal:

Journal of Toxicology and Environmental Health

Year:

2006

Language:

english

File:

PDF, 129 KB

english, 2006

46

Handbook of Toxicology of Chemical Warfare Agents || Behavioral Toxicity of Nerve Agents

Year:

2009

Language:

english

File:

PDF, 146 KB

english, 2009

47

Entry of oxime K027 into the different parts of rat brain: Comparison with obidoxime and oxime HI-6

Žďárová Karasová, Jana, Zemek, Filip, Kassa, Jiří, Kuča, Kamil

Journal:

Journal of Applied Biomedicine

Year:

2014

Language:

english

File:

PDF, 303 KB

english, 2014

48

Therapeutic efficacy of a novel bispyridinium oxime K203 and commonly used oximes (HI-6, obidoxime, trimedoxime, methoxime) in soman-poisoned male rats and mice

Kassa, Jiří, Karasová, Jana Žd'árová, Krejčiová, Markéta

Journal:

Journal of Applied Biomedicine

Year:

2013

Language:

english

File:

PDF, 340 KB

english, 2013

49

A comparison of cholinesterase inhibitors in the treatment of quinuclidinyl benzilate-induced behavioural deficit in rats performing the multiple T-maze

Misik, Jan, Kassa, Jiri

Journal:

Journal of Applied Biomedicine

Year:

2014

Language:

english

File:

PDF, 452 KB

english, 2014

50

Soman and VX: different effect on cellular signalling

Pejchal, Jaroslav, Österreicher, Jan, Kassa, Jiří, Tichý, Aleš, Šinkorová, Zuzana, Zárybnická, Lenka, Kubelková, Klára, Kuča, Kamil

Journal:

Journal of Applied Biomedicine

Year:

2012

Language:

english

File:

PDF, 3.40 MB

english, 2012

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